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These tools, developed by Jacques BARBET, are made available free of charge for use and distribution under  conditions.

List of tools:

  • Exponentials :You do not want to perform a thorough analysis of your kinetics, but only to calculate T½?    Use “exponentials”.

“Exponentials” adjusts up to 4 exponentials + a constant value, directly in your Excel spreadsheet. You
indicate with the mouse the areas where your data are stored and where the parameters should be
returned with their standard deviations. You choose the weighting mode and the number of iterations
and you get your results in a few clicks.
“Exponentials” is an add-in to Excel that uses a weighted least-squares algorithm, entirely written in
Visual Basic.

  • Interactions  : An Excel add-in for simulation and curve fitting of multiple equilibrium, titration and speciation systems.
  • Kinetics  :   This software is largely inspired from WinSAAM and its predecessors SAAM and ConSAAM, with whom the author familiarized at the NCI Laboratory of Mathematical Biology, in Bethesda, MD, in the years 1984 and 1985.”Kinetics” deals with the same questions in the environment of Excel spreadsheets.
  • Pharmacokinetics  :You want to perform a simple pharmacokinetic analysis by fitting exponentials to your data and calculating T½’s, volumes and AUC’s?

“Pharmacokinetics” adjusts up to 3 exponentials, directly in your Excel spreadsheet. You indicate with
the mouse the areas where your data are stored and where the parameters should be returned with
their standard deviations. You choose the weighting mode and the number of iterations and you get
your results in a few clicks.

  • PopKinex :This population pharmacokinetic software remains based on classical multi-compartment mathematical modelsii. Compartment modeling is described in more detail in the “Kinetics” software documentation.
  • Retriever  : Ever wanted to get data from a published graphic to test your own model and data fitting?

“Retriever” is the software you need: display the graph (many file formats are allowed: jpeg, png, gif, tiff, bmp), overlay axes (linear or log) on the graph, locate data points with the mouse: the coordinates are shown at the bottom of the window and recorded in an Excel (csv) file.

 

Sources can be obtained by express request to barbet@arronax-nantes.fr.

 

From April 2010 to June 2014, Jacques Barbet was the director of the Arronax GIP. Thereafter, Jacques Barbet was the leader of the ArronaxPlus Equipment of Excellence, which was selected as one the French Equipment of Excellence “Investissements d’Avenir” and he contributed to the creation of the IRON Laboratory of Excellence (coordinator: Prof. Françoise Kraeber-Bodéré) of the same program.Jacques Barbet is now senior scientific advisor for the Arronax GIP and the ArronaxPlus Equipment of Excellence. He is involved in translational projects on the use of innovative radionuclides in cancer imaging and therapy and the pharmacokinetics of tumor targeting.